Nerves and gut

Evolutionary perspectives of peptides from gut endocrine cells and nerves.

McDonald, T. J., Jornvall, H., Nilsson, G., Vagne, M., Ghatei, M., Bloom, S. R. & Mutt, V. (1979) Biochem. Biophys. Res. Commun. in the press Moody, A. J., Jacobsen, H. & Sundby, F. (1978) in Gut Hormones Bloom, S. R., ed.), pp. 369-378 Mutt, V. (1978) in Gastrointestinal Hormones and Pathology of the Digestive System (Grossman, M. I., Speranza, V., Basso, N. & Lezoche, E., eds.), pp. 133-146, ...

Appetite signaling: from gut peptides and enteric nerves to brain.

The signaling systems underlying eating behavior control are complex. The current review focuses on gastrointestinal (GI) signaling systems as physiological key functions for metabolic control. Many of the peptides that are involved in the regulation of food intake in the brain are also found in the enteric nervous system and enteroendocrine cells of the mucosa of the GI tract. The only identif...

Dual intrinsic and extrinsic origins of CGRP- and NPY-immunoreactive nerves of rat gut and pancreas.

The origins of nerves containing calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY), and substance P were investigated in the rat stomach, pancreas, and colon, using immunocytochemistry combined with retrograde tracing and surgical and chemical denervation procedures. Compared with nerves containing vasoactive intestinal polypeptide (VIP) and galanin, which have primarily local origin...

Gut Microbiota and Neuropsychiatric Disorders

Relationships between neurokinin receptor-expressing interstitial cells of Cajal and tachykininergic nerves in the gut

The so-called interstitial cells of Cajal (ICC) are distributed throughout the muscle coat of the alimentary tract with characteristic intramural location and species-variations in structure and staining. Several ICC sub-types have been identified: ICC-DMP, ICC-MP, ICC-IM, ICC-SM. Gut motility is regulated by ICC and each sub-type is responsible for the electrical activities typical of each gut...